PARP 1
GroundTruth™ Measurement of Single-Strand Break Sensing and
Repair Dynamics
Conclusion and Translational Relevance: PARP1 Activity GroundTruth™
ATM
GroundTruth™ Measurement of DDR Signaling Initiation and
Propagation
Conclusion and Translational Relevance: ATM Signaling GroundTruth™
Phospho-ATM (pATM)
GroundTruth™ Measurement of Activated DDR Signaling Domains
Conclusion and Translational Relevance: pATM Activation GroundTruth™
ATR
in progress..
in progress..
Phospho-ATR (pATR)
GroundTruth™ Measurement of Replication Stress–Driven Signaling
Conclusion and Translational Relevance: pATR Activation GroundTruth™
H2AX (Total)
GroundTruth™ Measurement of Chromatin Substrate
Availability and DDR Capacity
Conclusion and Translational Relevance: H2AX Chromatin GroundTruth™
γH2AX
GroundTruth™ Measurement of DNA Damage Signaling Domains
and Break Extent
Conclusion and Translational Relevance: γH2AX Functional GroundTruth™
RAD50 (MRN Complex)
GroundTruth™ Measurement of DSB Sensing and End Tethering
Conclusion and Translational Relevance: γH2AX Functional GroundTruth™
MRE11
GroundTruth™ Measurement of DNA End Processing and Resection Initiation
in progress...
NBS1
in progress...
in progress...
RAD51
GroundTruth™ Measurement of Homologous Recombination
Competency
Conclusion and Translational Relevance: RAD51 Functional HR
GroundTruth™
XRCC3
GroundTruth™ Measurement of Homologous Recombination
Stabilization and Resolution
in progress...
XRCC1
GroundTruth™ Measurement of Single-Strand Break Repair and
BER Coordination
in progress...
ATRIP
GroundTruth™ Measurement of Replication Stress Sensing and ATR Recruitment
Conclusion and Translational Relevance: ATRIP Functional GroundTruth™
BRCA1 / BRCA2
GroundTruth™ Measurement of End Resection and HR
Pathway Execution
Conclusion and Translational Relevance: BRCA1/2 Functional GroundTruth™
BRCA2
GroundTruth™ Measurement of RAD51 Loading and HR Execution
Conclusion and Translational Relevance: BRCA2 Functional GroundTruth™
FANC1 / Fanconi Axis
GroundTruth™ Measurement of Crosslink Repair Competency
Conclusion and Translational Relevance: FANCI/Fanconi Axis GroundTruth™
53BP1
GroundTruth™ Measurement of End Protection and Repair Pathway Bias
in progress...
BAP1.p
in progress..
in progress..
Ku70
in progress...
in progress...
